Regulation of Airway Tight Junctions by Proinflammatory Cytokines
نویسندگان
چکیده
منابع مشابه
Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells.
The epithelial lining of the gastrointestinal tract forms a regulated, selectively permeable barrier between luminal contents and the underlying tissue compartments. Permeability across the epithelium is, in part, determined by the rate-limiting barrier of the paracellular pathway-the most apical intercellular junction referred to as the tight junction (TJ). The TJ is composed of a multiprotein...
متن کاملRegulation of Tight Junctions in Upper Airway Epithelium
The mucosal barrier of the upper respiratory tract including the nasal cavity, which is the first site of exposure to inhaled antigens, plays an important role in host defense in terms of innate immunity and is regulated in large part by tight junctions of epithelial cells. Tight junction molecules are expressed in both M cells and dendritic cells as well as epithelial cells of upper airway. Va...
متن کاملDifferential regulation of gap junctions by proinflammatory mediators in vitro.
The development of inflammation is an important component of host defense against infection. The cellular and molecular processes underlying inflammation are well-studied, and it is known that cells of the blood vessel wall, such as endothelial cells and smooth muscle cells, play pivotal roles. Additionally, a wide variety of proinflammatory mediators have been defined, which coordinate the mul...
متن کاملRegulation of Nitric Oxide Synthesis by Proinflammatory Cytokines
We have examined cytokine regulation of nitric oxide synthase (NOS) in human umbilical vein endothelial cells (HUVEC). 24-h treatment with IFN-'y (200 U/ml) plus TNF (200 U/ml) or IL-1,8 (5 U /ml) increased NOS activity in HUVEC lysates, measured as conversion of I '4CIL-arginine to [ '4Cj L-citrulline. Essentially, all NOS activity in these cells was calcium dependent and membrane associated. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2002
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e02-03-0134